SymbOS has been developed originally for the Amstrad CPC. Because of the modular structure with the strict separation of general and hardware components the porting to other Z80-based systems is quite easy.
The MSX computers starting with the MSX2 standard are supported since summer 2006. The Amstrad [[PCW|PCW]] port is available since August 2007. Since end of 2014 the port for the [[Enterprise]] 64/128 has been done as well. Versions for Amstrad NC100/150/200 and PCW16, Spectrum Next and exist nowadays. And others , Z88 ... are possible, too, as they fulfill the requirements for SymbOS.
By keeping a basic condition for an operating system, the strict separation of hardware and application software by the supply of an intermediate layer, SymbOS applications run platform-independently on each computer and do not have to be adapted for a special system. Exceptions are applications, which access directly the hardware.